This study is the first to report long-term results of intradiscal PRP treatment in patients with symptomatic intervertebral disc degeneration.
Improvements in all pain and functional outcomes were sustained over time and met the definition of clinical significance. Nearly 75% of patients were classified as successes, and a third of the patients who underwent surgery believed that the PRP injection prolonged their need for surgery.
There were no significant associations between success and age, the number of levels injected, or whether multiple levels were injected. Future studies evaluating the effectiveness of PRP in LBP will need to be done in larger populations, and we should investigate ways of optimizing the PRP preparation for intradiscal application. In addition, future studies analyzing the success of patients according to the cellular characteristics of the blood drawn and the platelet yield in PRP may provide more insight into when the treatment is most effective.